Research shows Hyaluronic Acid and Botulinum Toxin combo works wonders
A new study recently published at Plastic and Reconstructive Surgery®, the official journal of ASPS (American Society of Plastic Surgeons) showed that the combination of Hyaluronic Acid with Botulinum Toxin (the substance used in the popular Botox), is able to prolong the action of Hyaluronic Acid. Dermal fillers is a really popular option for facial lines treatment (2.3 million procedures in 2014) consisting of natural gel-based products that are highly compatible to the body. But the fact that it degenerates pretty soon is a major drawback.. now this combo seems to change the scenery! The term “chemodenervation” is used to describe the effect of botulinum toxin.. The team of Dr. ?smail Küçüker (Ondokuz May?s University Faculty of Medicine in Samsun, Turkey) explain that botulinum toxin reduces the muscle activity in the treated area thus making it harder for the dermal filler to degenerate! So, the utilization of botulinum toxin paralyzes muscles in the treated area for a few months and this prolong the life of the dermal filler.
Dr Küçüker’s team decided to apply a study in rabbits injecting Hyaluronic Acid in front of each ear (this is an area that corresponds to the forehead region in humans). Botulinum toxin was injected only in one of the two ears. MRI scans were performed three months later to estimate the amount of the remaining filler. The results were pretty interesting while the injection of botulinum toxin reduced the amount of HA degeneration by 42%. Also the volume of the filler was 50% higher in the ear where botulinum toxin was used.
Dr. Küçüker summarizes: “This study showed that HA filler application in combination with BoNT-A significantly decreases the degradation process and increases the remaining volume at the end of the paralyzed period”.
This is a really interesting finding though a few other things need to be considered, like the cost of this combo!